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Those who are more likely suffering from this deficiency include anemics, vegans, vegetarians, people with multiple food allergies, and people who are over 50 years old

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Stefels J, Steinke M, Turner S, Malin G, Belviso S

Concomitant administration of cimetidine with tiotropium resulted in a 20% increase in the AUC0-4h, a 28% decrease in the renal clearance of tiotropium and no significant change in the Cmax and amount excreted in urine over 96 hours